Thus, although a camel cannot pass through the eye of a needle, it is extraordinary to imagine that every day its body weight’s equivalent in metabolites tunnel backward and forward through an integral membrane aperture ≈6 orders of magnitude smaller in diameter.
Susanna Törnroth-Horsefield and Richard Neutze on flux through the VDAC pore in “Opening and closing the metabolite gate”, Proceedings of the National Academy of Sciences, December 2008.